Understanding Letrozole: What Is It?

Letrozole is a medication primarily used in the treatment of certain types of breast cancer. It belongs to a class of drugs known as aromatase inhibitors, which play a crucial role in managing hormone-sensitive cancers.

How Does Letrozole Work?

The mechanism of action for letrozole involves inhibiting the aromatase enzyme, which converts androgens into estrogen. By lowering estrogen levels in the body, letrozole helps to slow or stop the growth of hormone-receptor-positive breast tumors. This is particularly effective in postmenopausal women whose cancer is fueled by estrogen.

Indications for Use

Letrozole is commonly prescribed for the following conditions:

Hormone receptor-positive breast cancer in postmenopausal women.
As an adjuvant therapy after surgery to reduce the risk of recurrence.
Treatment of advanced breast cancer that has progressed after tamoxifen therapy.

Dosage and Administration

Letrozole is typically taken orally in tablet form. The standard dosage is:

One 2.5 mg tablet once daily.
It can be taken with or without food.

Possible Side Effects

letrozole is generally well-tolerated, some patients may experience side effects, including:

Hot flashes.
Joint pain.
Fatigue.
Nausea.
Bone thinning (osteoporosis).

FAQs About Letrozole

1. Who should not take letrozole?

Letrozole is contraindicated in individuals who are pregnant or breastfeeding, and those with a hypersensitivity to any component of the medication.

2. Can letrozole be used for fertility treatment?

Yes, letrozole is sometimes used off-label https://letrozole-for-sale.com/medicament/letrozol-zentiva-filmtabletten-2-5mg-100-stuck/ for ovulation induction in women with infertility issues, as it can stimulate ovarian function.

3. How long is letrozole usually prescribed?

The duration of treatment with letrozole varies based on the individual’s specific condition and response to therapy. Typically, it is prescribed for five years as part of adjuvant therapy.

Conclusion

Letrozole is a vital medication in the fight against hormone-sensitive breast cancer, providing significant benefits for many patients. Its ability to effectively lower estrogen levels contributes to its success in slowing tumor growth and improving patient outcomes.